With his big arm, “The Mad Bomber” became a nickname for Lamonica, who played before the game became more pass-heavy. In 12 seasons with the Bills and Raiders, he had a record of 66-16-6. He threw for 19,154 yards, 164 touchdowns, and 138 interceptions. When he was running, he also scored 14 times.
His Raiders won two MVP awards in 1967 and 1969. In the AFL, he was the MVP in the championship game for 1967. For two years, he won two AFL championships with the Bills. He then won with the Raiders in 1967, his first year with the team.
Afterwards, he was chosen in both the 1963 AFL draft and NFL draft by the Bills and Packers. He chose to play for Buffalo, where he was a run-first player behind Bills quarterback Jack Kemp. He was traded to Oakland in 1967, where he played for the Raiders. When the team played that year, they went 13–1 and won the AFL championship over the Houston Oilers. They lost to the Green Bay Packers in Super Bowl II, though.
When the AFL and NFL merged in 1970, he was a second-team All-Pro. Ken Stabler, another great Raiders player, took over for him when he played less in 1973. Afterward, he played in the new World Football League for the Southern California Sun for a year.
Lamonica is a big fan of the outdoors. He also hosted a fishing show for Fox Sports Net called Outdoors With the Pros.